With long term

Question

While prescription opioids tend to be relatively safe when used as directed, all opioids present a risk of misuse, and with long-term misuse can come the possibility of developing an opioid use disorder. Once this disorder develops, few people are able to overcome their opioid misuse without help.

https://www.themanorclinic.com/prescription-drugs/opioids/

I am doing my CPD( continuing professional development) on meds used for opioids detox.

please explain the use of "with" in "with long term..."

which meaning of "with" is used here?https://dictionary.cambridge.org/dictionary/english/with?q=With

Is "with long term use" an adverb in the sentence or just a subject in the sentence of the predicate "can come...?"

CalifJim · Accepted Answer

JigneshbharatiPlease explain the use of "with" in "with long-term ..."

B2 — in the case of

JigneshbharatiIs "with long term use" an adverb in the sentence or just a subject in the sentence of the predicate "can come...?"

"with long term use" has four words. The term "adverb" can describe only one word. Some adverbs are here, today, soon, quickly, and carefully.

"with long term use" is a prepositional phrase.

Jigneshbharatia subject in the sentence of the predicate "can come...?"

No. The subject is the possibility of developing an opioid use disorder.

If the clause had not been inverted, it would have read thus:

... the possibility of developing an opioid use disorder can come with long-term misuse.

CJ

With long term

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