He was able to seduce a lot of women with his tiny hands.
I don't think with makes grammatical sense since he's not seducing with them, but he has them, but can you still say it? I feel you can say this, to mean despite, but in a less 'negative' way.
I'd say this. He was able to seduce a lot of women despite his tiny hands. Although he had tiny hands, he was able to seduce a lot of women.
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I'd say this.
He was able to seduce a lot of women despite his tiny hands.
Although he had tiny hands, he was able to seduce a lot of women.
But do you really think that women don't like men with tiny hands?
Clive