{"id":23697,"date":"2019-10-07T14:30:41","date_gmt":"2019-10-07T14:30:41","guid":{"rendered":"https:\/\/www.englishforums.com\/news\/?p=23697"},"modified":"2019-10-07T14:30:41","modified_gmt":"2019-10-07T14:30:41","slug":"pitt-hopkins-microbiota-therapy","status":"publish","type":"post","link":"https:\/\/www.englishforward.com\/news\/pitt-hopkins-microbiota-therapy\/","title":{"rendered":"Pitt Hopkins microbiota transfer therapy, newfound hope"},"content":{"rendered":"<p><strong>Pitt Hopkins-associated gastrointestinal challenges might be eradicated by microbiota transfer therapy. A research program at Arizona State University (ASU) aims to solve constipation issues associated with the disorder.<\/strong><\/p>\n<h2>Pitt Hopkins syndrome<\/h2>\n<p>Children with the syndrome lack a gene called TCF4 on their 18th chromosome. Persons with <a href=\"https:\/\/ktar.com\/story\/2777791\/asu-conducting-first-human-study-for-rare-chromosomal-condition\/\" target=\"_blank\" rel=\"noopener\">Pitt Hopkins syndrome<\/a> have difficulty walking and talking. They also have constipation challenges such that going to the bathroom becomes a struggle.<br \/>\nPitt Hopkins wasn\u2019t diagnosed until 2007, and Arizona has a record of 7 children with the disorder. Nicole Anderson, an alumnus of Arizona State University, also has a child with the disorder, Alexandra, one of about 1,000 people in the world with a rare neurodevelopment disorder.<\/p>\n<h2>Pitt Hopkins Microbiota Transfer Therapy<\/h2>\n<p>The ASU research program will modify the gut microbiome of individuals with Pitt Hopkins syndrome. Similar research was performed on persons with <a href=\"https:\/\/www.englishforums.com\/news\/awareness-of-autism-at-schools\/\" target=\"_blank\" rel=\"noopener\">Autism<\/a> Spectrum Disorders, and substantial improvements were recorded. Treated patients reported that their symptoms reduced by 80 percent.<br \/>\nThe disorder is classified on the autism spectrum, the reason for the research at ASU. <strong>The director of the research program, James Adams, believes that modifying the gut microbiome in children with ASD improves their gastrointestinal (GI) and behavioral symptoms.<\/strong><br \/>\nAdams&#8217; research team observed an abnormal gut microbiota in individuals with Autism Spectrum Disorders (ASD). This suggested a link between Autism Spectrum Disorders and the gut microbiome. The gastrointestinal symptoms associated with the disorder is believed to also benefit from this gut microbiome correction.<br \/>\n<strong>The microbiota transfer therapy will introduce commensal microbes into the guts and potentially build up to effectively chronic gut problems in children with Pitt Hopkins syndrome.<\/strong><br \/>\nThe ASU autism\/Asperger\u2019s Research Program is the first to conduct a human clinical trial for the disorder, which will begin in early 2020.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pitt Hopkins-associated gastrointestinal challenges might be eradicated by microbiota transfer therapy. A research program at Arizona State University (ASU) aims to solve constipation issues associated with the disorder. Pitt Hopkins syndrome Children with the syndrome lack a gene called TCF4 on their 18th chromosome. Persons with Pitt Hopkins syndrome have difficulty walking and talking. They [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":23700,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[25,26],"tags":[],"_links":{"self":[{"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/posts\/23697"}],"collection":[{"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/comments?post=23697"}],"version-history":[{"count":0,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/posts\/23697\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/media\/23700"}],"wp:attachment":[{"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/media?parent=23697"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/categories?post=23697"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/tags?post=23697"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}