{"id":19862,"date":"2019-08-16T17:41:05","date_gmt":"2019-08-16T17:41:05","guid":{"rendered":"https:\/\/www.englishforums.com\/news\/?p=19862"},"modified":"2019-08-16T17:41:05","modified_gmt":"2019-08-16T17:41:05","slug":"breakthrough-breast-cancer-cells-fat","status":"publish","type":"post","link":"https:\/\/www.englishforward.com\/news\/breakthrough-breast-cancer-cells-fat\/","title":{"rendered":"Scientific breakthrough: Turning breast cancer cells to fat cells"},"content":{"rendered":"

A study paper published in Cancer Cell<\/a> in early 2019, revealed a scientific breakthrough which gave breast cancer patients a new way to turn cancer cells into fat.\u00a0<\/strong><\/em>
\nIt was conducted by a team of researchers in Switzerland at the University of Basel. The team worked with a group of mice which they implanted a form of aggressive human breast cancer cells.\u00a0<\/span>
\nThe researchers then treated them with rosiglitazone, an antidiabetic drug, as well as administering cancer treatment called trametinib.\u00a0<\/strong>
\nThe process can only be done when the team made a weird pathway they could use by metastasizing cancer cells.\u00a0<\/span>
\nFor that, the team experimented and use the method called epithelial-mesenchymal transition (EMT). The process involves changing the epithelium formation – which is when wounds on the skin occur or forming new organ tissues for the fetus – to a more fluid type of stem cell called mesenchyme.\u00a0<\/strong><\/span>
\nA 2016 study stated that by using EMT is possible for cancer to use to create a pathway and metastasise. The said study also concluded that using the reverse pathway called mesenchymal-to-epithelial transition (MET) can be used as well.<\/span>
\nOnce the drugs were administered by using the transition pathways, the spreading of the cancer cells was stopped.<\/strong> And instead, it turned into fat cells which the researchers called the process as adipogenesis.<\/span>
\nAs the team penned in their paper:<\/span><\/p>\n

The results indicate that in a patient-relevant setting combined therapy with rosiglitazone and trametinib specifically targets cancer cells with increased plasticity and induces their adipogenesis.\u00a0<\/span><\/p><\/blockquote>\n

The result shows that every cancer cell which underwent change into the fat cell was successful since the \u201cnew fat cells\u201d didn\u2019t change back as potential malignant cancer cells.\u00a0<\/strong><\/span>
\nA biochemistry professor at the University of Bael, <\/span>Gerhard Christofori<\/span><\/a>, told that \u201ccancer cells that underwent an EMT\u201d process did not only changed but were \u201calso completely stopped proliferating.\u201d\u00a0<\/strong><\/span>
\nHe also added that this confirms that the \u201ccancer cells-turned-fat cells\u201d will stay as fat cells and will “not revert back to breast cancer cells.\u201d<\/span><\/p>\n

How cancer cells were stopped<\/b><\/h2>\n

When the trametinib drug was applied, it boosts the transition process of the cancer cells to turn into stem cells. Which then also increases the reconstruction of the turned stem cells into fat cells.\u00a0<\/span>
\nThe combination of trametinib drug to rosiglitazone while executing the <\/span>adipogenic<\/span><\/a> differentiation therapy helped the efficient conversion of stem cells into fat cells.\u00a0<\/span>
\n

\"\"
CREDIT: DEPARTMENT OF BIOMEDICINE, UNIVERSITY OF BASEL.<\/figcaption><\/figure>
\nThese images were released by Department of Biomedicine at the University of Basel. The green fluorescent protein (GFP) in the left image indicates cancer cells while the normal lipid-filled adipocyte can be seen as red.<\/span>
\nOn the other hand, the odd-looking dark-yellowish orbs were the converted GFP-expressing cancer cells – which were previously green.\u00a0<\/span>
\nThe reason why it changed color was that it underwent trans-differentiation therapy, which led to combining the red color to green and then resulted in the change of dark-yellow hue.<\/span>
\nMany mouse-tested clinical treatments were done in the past and usually failed during the trial stage. However, the breakthrough of this cancer cell treatment showed promise even though it was still in their first step process.<\/span>
\nAs of this moment, the team is taking extra measures of it is possible to combine it with chemotherapy as well as testing it if it can be applied for other types of cancers.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

A study paper published in Cancer Cell in early 2019, revealed a scientific breakthrough which gave breast cancer patients a new way to turn cancer cells into fat.\u00a0 It was conducted by a team of researchers in Switzerland at the University of Basel. The team worked with a group of mice which they implanted a […]<\/p>\n","protected":false},"author":9,"featured_media":19869,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[17],"tags":[761,1407],"_links":{"self":[{"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/posts\/19862"}],"collection":[{"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/comments?post=19862"}],"version-history":[{"count":0,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/posts\/19862\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/media\/19869"}],"wp:attachment":[{"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/media?parent=19862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/categories?post=19862"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.englishforward.com\/news\/wp-json\/wp\/v2\/tags?post=19862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}